rs10455872
rs10455872 is an intronic A>G variant in intron 25 of LPA, the gene encoding apolipoprotein(a), with the minor G allele present at roughly 7% frequency. The risk allele tracks with a smaller apolipoprotein(a) kringle IV-2 repeat isoform and is one of the strongest known determinants of elevated plasma lipoprotein(a), Lp(a), which in turn raises coronary artery disease risk (odds ratio around 1.7) independent of LDL cholesterol.
Traits rs10455872 reads
Gene
Reference databases
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