rs17782313
rs17782313 is a common intergenic variant located about 188 kb downstream of MC4R (melanocortin-4 receptor), a hypothalamic receptor central to appetite and energy-balance regulation, rather than a coding change in the gene itself. The risk (C) allele has been linked to altered MC4R promoter methylation and changes in MC4R mRNA expression in expression-QTL studies, though the direction of the effect differs by tissue and brain region. It is one of the most replicated GWAS loci for higher BMI, fat mass, and obesity risk, and is used alongside FTO rs9939609 in polygenic weight/appetite risk scoring.
Traits rs17782313 reads
Gene
Reference databases
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