rs13376333
rs13376333 is an intronic variant in KCNN3, the gene encoding the small-conductance calcium-activated potassium channel SK3, located between the gene's first and second exons. In native and stem-cell-derived human atrial myocytes, the risk allele reduces SK-current density — a loss-of-function effect on the channel that mimics the electrical remodeling seen in atrial fibrillation. It is one of the loci, alongside PITX2 rs2200733 and ZFHX3 rs7193343, used to build polygenic risk scores for atrial fibrillation.
Traits rs13376333 reads
Gene
Reference databases
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