Gene

KCNN3

KCNN3 encodes SK3, a small-conductance calcium-activated potassium channel expressed in cardiac atrial tissue and neurons, where calcium influx opens the channel to shape action-potential repolarization and refractory period. Common variants at the KCNN3 locus, including rs13376333, are established GWAS hits for atrial fibrillation risk, likely by altering atrial repolarization currents and electrical stability.

Traits KCNN3 shapes

Atrial fibrillation risk

Markers (rsIDs)

rs13376333

Reference databases

HGNC gene symbol report: KCNN3
NCBI Gene: KCNN3

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