rs12722
rs12722 is a C>T variant in the 3' untranslated region of COL5A1, which encodes the alpha1 chain of type V collagen, a regulator of collagen fibril assembly in tendons and ligaments. The T allele increases COL5A1 mRNA stability and is linked to altered fibril structure, while the C allele (CC genotype) has been associated with reduced risk of tendon/ligament soft-tissue injuries (e.g., Achilles tendinopathy, ACL injury) in Caucasian cohort meta-analyses. This is the basis for its use as a marker of muscle-soreness/soft-tissue-injury susceptibility and connective-tissue context.
Traits rs12722 reads
Gene
Reference databases
How Biome reads this
Biome's at-home DNA test reads this directly from one saliva sample, alongside 650,000+ other markers.
Biome DNA test →This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.