Gene

COL5A1

COL5A1 encodes the alpha-1 chain of type V collagen, a minor fibrillar collagen that nucleates and regulates the diameter of type I collagen fibrils in tendons, ligaments, and skin. A 3' UTR variant tagged by rs12722 is associated with tendon and ligament stiffness, and has been linked in multiple studies to susceptibility to soft-tissue injuries (e.g., Achilles tendinopathy) and exercise-induced muscle soreness.

Traits COL5A1 shapes

Tendon & ligament injury tendency
Soft-tissue injury tendency

Markers (rsIDs)

rs12722

Reference databases

HGNC gene symbol report: COL5A1
NCBI Gene: COL5A1

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.