rs10305420
rs10305420 is a missense variant in GLP1R, c.20C>T causing Pro7Leu near the receptor's N-terminal signal peptide. In a 23andMe genome-wide association study of over 27,000 people taking GLP-1 receptor agonists (semaglutide, tirzepatide), the effect allele was associated with greater weight loss (about 0.64% additional BMI reduction per allele), and the locus colocalizes with signals for GLP-1-related nausea and vomiting.
Traits rs10305420 reads
Gene
Reference databases
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