GLP1R
GLP1R encodes the glucagon-like peptide-1 receptor, a class B1 G-protein-coupled receptor on pancreatic beta cells, the hypothalamus, and the gut that binds GLP-1 to stimulate glucose-dependent insulin secretion, suppress glucagon, and slow gastric emptying. It is the direct molecular target of GLP-1 receptor agonist drugs such as semaglutide and liraglutide, and variants including rs10305420 are studied for their association with weight-loss response and nausea/GI side effects on these medications.
Traits GLP1R shapes
Markers (rsIDs)
Reference databases
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