DIO2
DIO2 encodes type 2 iodothyronine deiodinase, an intracellular enzyme found in the thyroid, skeletal muscle, heart, and brain that converts thyroxine (T4) into the biologically active hormone triiodothyronine (T3), providing tissue-level control of thyroid hormone action independent of circulating hormone levels. Variants such as rs225014 (Thr92Ala) are associated with altered enzyme activity and have been linked to differences in T4-to-T3 conversion efficiency and downstream metabolic and cognitive traits.
Traits DIO2 shapes
Markers (rsIDs)
Reference databases
How Biome reads this
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