rs992969
rs992969 lies in a regulatory/intronic region near IL33, a gene encoding an epithelial-derived alarmin cytokine that drives type 2 (allergic) immune responses. In multi-ancestry GWAS and fine-mapping of the IL33 locus it is one of the top credible-set variants (posterior inclusion probability ~0.39) for asthma and elevated blood eosinophil counts, with the risk allele linked to increased local IL33 expression. It is combined with GSDMB/ORMDL3 (rs4795399) and IL1RL1 (rs72823641) variants alongside a genome-wide asthma polygenic score to estimate lifetime asthma and allergic-disease risk.
Traits rs992969 reads
Gene
Reference databases
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