rs7903146
rs7903146 is an intronic variant in TCF7L2 (transcription factor 7-like 2) on chromosome 10q25, the single strongest and most widely replicated common genetic risk locus for type 2 diabetes. The T risk allele is associated with impaired pancreatic beta-cell insulin secretion and blunted incretin hormone action, raising fasting glucose and HbA1c, with a pooled odds ratio near 1.46 per T allele across populations. It is a core contributor, combined with genome-wide polygenic scores, to type 2 diabetes risk assessment.
Traits rs7903146 reads
Gene
Reference databases
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