rs72823641
rs72823641 is an intronic variant in IL1RL1 on chromosome 2, the gene encoding the ST2 receptor for interleukin-33 (IL-33) and its soluble decoy form (sST2), which together regulate type 2 immune and allergic inflammatory signaling. Variation at this locus has been repeatedly associated with asthma and allergic disease risk in genome-wide association studies, including a UK Biobank cross-trait analysis where it was among the strongest signals shared across asthma and allergic conditions. In this dataset it contributes, alongside a 17q21 GSDMB/ORMDL3 signal and IL33 rs992969, to a polygenic score for lifetime asthma and allergic disease risk.
Traits rs72823641 reads
Gene
Reference databases
How Biome reads this
Biome's at-home DNA test reads this directly from one saliva sample, alongside 650,000+ other markers.
Biome DNA test →This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.