rs2066845
rs2066845 is the NOD2 Gly908Arg (G908R) missense variant, one of three principal NOD2 coding variants associated with Crohn's disease risk. Like Arg702Trp and Leu1007fsinsC, it falls in the leucine-rich repeat domain that normally lets NOD2 detect bacterial muramyl dipeptide, and the substitution impairs this innate-immune sensing function. It contributes to inflammatory bowel disease genetic risk, particularly for Crohn's disease.
Traits rs2066845 reads
Gene
Reference databases
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