rs1801725
rs1801725 is the CASR Ala986Ser (A986S) missense variant in the calcium-sensing receptor gene, located in the receptor's cytoplasmic tail. The Ser986 allele produces a less-active receptor with reduced sensitivity to extracellular calcium, shifting the calcium set-point and associating with modestly higher serum calcium and parathyroid hormone levels. Along with CYP24A1 rs1570669, it is used as inherited context for calcium status within the normal range.
Traits rs1801725 reads
Gene
Reference databases
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