Marker

rs1800629

rs1800629 is a G>A promoter variant located 308 base pairs upstream of the transcription start site of TNF (tumor necrosis factor-alpha), distinguishing the common TNF1 (G) allele from the less common TNF2 (A) allele. Reporter and clinical studies link the A allele to increased TNF-alpha transcriptional activity and higher circulating TNF-alpha levels. Along with IL6 rs1800795, it is used as inherited context for baseline inflammatory-signaling tone.

Traits rs1800629 reads

TNF-α inflammatory signalling

Gene

Reference databases

dbSNP: rs1800629

How Biome reads this

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.