Marker

rs113851554

rs113851554 is a common intronic variant in MEIS1 on chromosome 2, a gene previously implicated in restless legs syndrome, insomnia, and chronotype. In a genome-wide association study of device-measured sleep in roughly 80,000 UK Biobank participants, it was the lead signal for sleep-stage balance, associated with longer REM sleep duration and shorter NREM sleep duration in opposite directions, with a posterior probability of causality near 100%. It is used with two other MEIS1 intronic variants (rs4544423, rs182588061) and KCNK9 rs888346 to inform genetic REM-versus-NREM sleep architecture.

Traits rs113851554 reads

REM vs deep-sleep balance (MEIS1)

Gene

MEIS1

Reference databases

dbSNP: rs113851554

How Biome reads this

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.