rs11209026
rs11209026 is a coding missense variant in IL23R (c.1142G>A), producing the p.Arg381Gln (R381Q) amino-acid substitution in the interleukin-23 receptor, which is expressed on T cells and mediates IL-23 signaling in chronic inflammation. The Gln381 variant is hypomorphic, reducing IL-23 receptor signaling, and confers strong protection against Crohn's disease and ulcerative colitis. In this dataset it is listed as a protective marker within the broader inflammatory bowel disease polygenic risk score alongside NOD2 and ATG16L1 variants.
Traits rs11209026 reads
Gene
Reference databases
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