Gene

TCN2

TCN2 encodes transcobalamin II, the plasma transport protein that binds dietary vitamin B12 (cobalamin) after intestinal absorption and delivers it into cells via receptor-mediated endocytosis, making it the main determinant of B12 delivery to tissues. The common variant rs1801198 (Pro259Arg) affects transcobalamin binding affinity and is associated with circulating vitamin B12 and holotranscobalamin status.

Traits TCN2 shapes

Active B12 delivery

Markers (rsIDs)

rs1801198

Reference databases

HGNC gene symbol report: TCN2
NCBI Gene: TCN2

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.