SOD2
SOD2 encodes manganese superoxide dismutase (MnSOD), a mitochondrial matrix enzyme that converts the superoxide radical (O2•−) generated by oxidative phosphorylation into hydrogen peroxide and oxygen, forming a first-line defense against mitochondrial oxidative stress. The common Val16Ala variant (rs4880) in the mitochondrial targeting sequence affects how efficiently the enzyme is imported into mitochondria and has been studied for its influence on cellular antioxidant capacity and oxidative-stress-related disease risk.
Traits SOD2 shapes
Markers (rsIDs)
Reference databases
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