RXRA
RXRA (retinoid X receptor alpha) encodes a nuclear hormone receptor activated by 9-cis retinoic acid that heterodimerizes with partners such as RAR, PPAR, and VDR to control transcription of genes governing cell differentiation and lipid metabolism. In skin, RXRA-dependent retinoid signaling regulates sebocyte differentiation and lipid production within the pilosebaceous unit, the biological basis for its connection to oil-gland activity and for retinoids being a mainstay acne treatment.
Traits RXRA shapes
Reference databases
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