Gene

PTPRD

PTPRD (protein tyrosine phosphatase receptor type D) encodes a neuronal cell-surface adhesion molecule that organizes synapse formation and has been linked to dopaminergic signaling pathways in the brain. PTPRD is one of the earliest and most consistently replicated GWAS loci for restless legs syndrome, a condition also tied to disrupted brain iron handling, which is why clinicians evaluate iron status alongside this genetic risk.

Traits PTPRD shapes

Restless legs syndrome risk

Reference databases

HGNC gene symbol report: PTPRD
NCBI Gene: PTPRD

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.