Gene

PSRC1

PSRC1 encodes proline and serine rich coiled-coil 1, a microtubule-binding protein involved in mitotic spindle regulation. It sits at the 1p13 CELSR2-PSRC1-SORT1 locus, where common regulatory variants are strongly associated with blood LDL cholesterol. PSRC1 transcript levels change with genotype at this locus, but functional work points to SORT1 as the gene mediating the cholesterol effect.

Traits PSRC1 shapes

LDL cholesterol tendency (SORT1 locus)

Markers (rsIDs)

rs12740374

Reference databases

HGNC gene symbol report: PSRC1
NCBI Gene: PSRC1

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.