PPARGC1A
PPARGC1A encodes PGC-1alpha, a transcriptional coactivator that partners with PPARgamma and other nuclear receptors to drive mitochondrial biogenesis, oxidative metabolism, and the fiber-type switching that occurs in skeletal muscle in response to endurance exercise. Common variants such as rs8192678 (Gly482Ser) have been studied for their association with aerobic exercise trainability and VO2max response, reflecting the gene's central role in the muscle's mitochondrial adaptation to training.
Traits PPARGC1A shapes
Markers (rsIDs)
Reference databases
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