LRRK2
LRRK2 (leucine-rich repeat kinase 2) encodes a large multidomain protein with both GTPase and kinase activity that regulates vesicle trafficking, lysosomal function, and autophagy in neurons and immune cells. Missense variants in LRRK2 (such as G2019S) are among the most common known genetic contributors to both familial and sporadic Parkinson's disease, making the gene a central focus of Parkinson's risk and drug-target research.
Traits LRRK2 shapes
Markers (rsIDs)
Reference databases
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