CYP2C9
CYP2C9 encodes a hepatic cytochrome P450 enzyme responsible for metabolizing many commonly prescribed drugs, including warfarin, phenytoin, and NSAIDs such as ibuprofen and celecoxib. Reduced-function alleles (notably *2 and *3) slow the clearance of these substrates, increasing bleeding risk with warfarin and raising exposure to NSAIDs and phenytoin, which is why CYP2C9 genotype informs dosing guidance for this substrate group.
Traits CYP2C9 shapes
Reference databases
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