CFH
CFH encodes complement factor H, a plasma glycoprotein that regulates the alternative complement pathway by inhibiting C3 convertase and protecting host cell surfaces (including retinal tissue) from complement-mediated damage. Common CFH variants, including the Y402H-associated haplotype tagged by rs1061170, are among the strongest known genetic risk factors for age-related macular degeneration, acting alongside ARMS2/HTRA1 and modifiable factors like smoking.
Traits CFH shapes
Markers (rsIDs)
Reference databases
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