Gene

APOE

APOE encodes apolipoprotein E, a lipid-transport protein that packages cholesterol into lipoprotein particles for transport in blood and, in the brain, mediates lipid delivery to neurons and clearance of amyloid-beta. The combination of rs429358 and rs7412 defines the e2/e3/e4 alleles, and the e4 allele is the strongest common genetic risk factor for late-onset Alzheimer's disease, largely through reduced amyloid clearance.

Traits APOE shapes

APOE Alzheimer's-risk type

Markers (rsIDs)

rs429358
rs7412

Reference databases

HGNC gene symbol report: APOE
NCBI Gene: APOE

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.