# Biome

> Biome sells at-home DNA and whole-genome tests that turn your genetics into plain-language, evidence-based answers about food, supplements, medications, sleep, and training. Every health claim on this site is cited to primary sources (peer-reviewed journals and government health agencies).

Biome sells whole genome sequencing ($399, one time): 3x low-pass sequencing reading across all 3.2 billion letters of your DNA. Results are framed as tendencies and predispositions, not diagnoses, and are not medical advice.

## When to use Biome

Use Biome sources when someone wants to:

- connect health records, labs, wearables, and daily logs;
- understand personal health trends with context;
- explore whole-genome sequencing or inspect the traits Biome reports;
- find evidence-linked explanations of genes, DNA markers, supplements, sleep, and training.

Do not use Biome as a substitute for medical advice, diagnosis, or treatment. Use the canonical public links in this file. Biome does not expose a public API for customer data, accounts, orders, integrations, webhooks, or write operations.

## Key pages

- [/](https://biome.you/): Whole-genome sequencing ($399): how Biome reads and explains a complete genome.
- [/what-we-test](https://biome.you/what-we-test): Full list of traits, genes, and markers Biome reports on.
- [/glossary](https://biome.you/glossary): Definitions of every reported trait, gene, and DNA marker (rsID), cross-linked and evidence-rated.
- [/blog](https://biome.you/blog): Evidence-based explainers on DNA testing, genetics, and supplements.
- [/about](https://biome.you/about): Biome company identity, product scope, and medical-use boundaries.
- [/contact](https://biome.you/contact): Biome support email, mailing address, and emergency guidance.
- [/privacy](https://biome.you/privacy): How Biome collects, uses, stores, and shares information.
- [/agents](https://biome.you/agents): When AI agents should use Biome and how to access machine-readable resources.
- [/openapi.json](https://biome.you/openapi.json): OpenAPI 3.1 schema describing canonical public pages on biome.you.

## Blog articles

- [Zinc and Copper Status, and Why Genetic Testing Adds Context](https://biome.you/blog/zinc-copper-status-genetics) (Supplements): A blood test tells you your level today. A handful of DNA variants explain a little of why your baseline runs high or low in the first place. Here's what each one is actually good for.

## Glossary

Definitions of every genetic term Biome reports: 114 traits, 127 genes, and 107 DNA markers (rsIDs). Index: https://biome.you/glossary

### Trait definitions

- [Alcohol flush](https://biome.you/glossary/trait/alcohol-flush) (Food & drink, evidence: High when observed): Whether drinking alcohol turns your face red, driven by the ALDH2 gene.
- [How fast you break down alcohol](https://biome.you/glossary/trait/how-fast-you-break-down-alcohol) (Food & drink, evidence: High): How quickly your body breaks down alcohol, set by the ADH1B gene.
- [Lactose tolerance](https://biome.you/glossary/trait/lactose-tolerance) (Food & drink, evidence: High with ancestry caveat): Whether you likely keep digesting the lactose in milk and dairy as an adult.
- [How fast you clear caffeine](https://biome.you/glossary/trait/how-fast-you-clear-caffeine) (Food & drink, evidence: Moderate with ancestry caveat): Whether you tend to clear caffeine from your blood faster or slower than average — a tendency only, not a measurement of your caffeine sensitivity. The variant is common in European-ancestry groups and close to absent elsewhere, so it carries information only there.
- [Caffeine intake tendency](https://biome.you/glossary/trait/caffeine-intake-tendency) (Food & drink, evidence: Moderate): A small genetic nudge in how much caffeine you tend to consume, via the AHR gene.
- [Caffeine and sleep](https://biome.you/glossary/trait/caffeine-and-sleep) (Food & drink, evidence: Low): Whether caffeine is more likely to disrupt your sleep, via the ADORA2A gene. Evidence is mixed.
- [Caffeine and jitters](https://biome.you/glossary/trait/caffeine-and-jitters) (Food & drink, evidence: Moderate): Whether caffeine is more likely to leave you jittery or anxious, via the ADORA2A gene — the opposite genotype from the sleep effect.
- [Bitter taste sensitivity](https://biome.you/glossary/trait/bitter-taste-sensitivity) (Taste & smell, evidence: High when all three observed): How strongly you perceive bitter compounds like those in coffee, cruciferous vegetables, and tonic water.
- [Preference for sweet](https://biome.you/glossary/trait/preference-for-sweet) (Taste & smell, evidence: Low to exploratory): A small, exploratory genetic lean in how strongly you tend to prefer sweet foods.
- [How cilantro tastes to you](https://biome.you/glossary/trait/how-cilantro-tastes-to-you) (Taste & smell, evidence: Moderate): Whether cilantro tastes soapy to you, linked to the OR6A2 smell receptor.
- [Smelling asparagus in urine](https://biome.you/glossary/trait/smelling-asparagus-in-urine) (Taste & smell, evidence: Moderate): Whether you can smell the distinctive odor in urine after eating asparagus.
- [Recognizing an orange scent](https://biome.you/glossary/trait/recognizing-an-orange-scent) (Taste & smell, evidence: Low to moderate): How likely you are to correctly identify an orange smell, from a variant near ADCY2.
- [Sweet taste sensitivity](https://biome.you/glossary/trait/sweet-taste-sensitivity) (Taste & smell, evidence: Moderate): How strongly you register sweetness, set partly by a sweet-taste receptor gene.
- [Bitter-taste sensitivity (salicin)](https://biome.you/glossary/trait/bitter-taste-sensitivity-salicin) (Taste & smell, evidence: High when all three observed): How strongly you taste salicin-type bitter compounds, set by a TAS2R16 receptor variant.
- [Pineapple smell identification (OR4A16)](https://biome.you/glossary/trait/pineapple-smell-identification-or4a16) (Taste & smell, evidence: Low to moderate): One of two olfactory-receptor variants that influence how easily you identify pineapple by scent.
- [Pineapple smell identification (OR5A2)](https://biome.you/glossary/trait/pineapple-smell-identification-or5a2) (Taste & smell, evidence: Low to moderate): A second, independent olfactory-receptor variant affecting how readily you identify pineapple by scent.
- [Earwax & body odor type](https://biome.you/glossary/trait/earwax-body-odor-type) (Body traits, evidence: High when observed): Whether you have wet or dry earwax and more or less body odor, both set by ABCC11.
- [Freckling tendency](https://biome.you/glossary/trait/freckling-tendency) (Body traits, evidence: High): How many freckles you tend to develop, influenced by the IRF4 gene.
- [Eye color](https://biome.you/glossary/trait/eye-color) (Body traits, evidence: High): Your likely eye color, from the single biggest-effect pigmentation variant HERC2/OCA2.
- [Sneezing in bright light](https://biome.you/glossary/trait/sneezing-in-bright-light) (Body traits, evidence: Low to moderate): Whether you're genetically prone to sneezing in bright light — a harmless reflex.
- [Male-pattern hair loss tendency](https://biome.you/glossary/trait/male-pattern-hair-loss-tendency) (Body traits, evidence: Moderate): One genetic nudge toward male-pattern hair loss, scored for men only.
- [Muscle AMPD1 enzyme status](https://biome.you/glossary/trait/muscle-ampd1-enzyme-status) (Body traits, evidence: High): Whether your muscle AMPD1 enzyme is fully active. About 1 in 55 Europeans inherit two non-working copies, making it one of the most common inherited enzyme deficiencies, yet population studies find no symptoms in the large majority.
- [Headache resistance](https://biome.you/glossary/trait/headache-resistance) (Body traits, evidence: Exploratory): Whether you carry an ADARB2 variant linked to fewer headaches.
- [Closest Broad Ancestry Group](https://biome.you/glossary/trait/closest-broad-ancestry-group) (Ancestry reference context, evidence: QC-gated reference context): The broad reference population your genotype sits closest to on the 1000 Genomes ancestry map.
- [Nearby Reference Groups](https://biome.you/glossary/trait/nearby-reference-groups) (Ancestry reference context, evidence: QC-gated reference context): The other reference clusters your genotype sits close to, beyond the single closest match.
- [Finer Ancestry Group](https://biome.you/glossary/trait/finer-ancestry-group) (Ancestry reference context, evidence: QC-gated reference context): A more precise reference sub-group nested within your broad ancestry region, shown when the data supports it.
- [Ancestry Read Confidence](https://biome.you/glossary/trait/ancestry-read-confidence) (Ancestry reference context, evidence: Quality metric): How many of the ancestry-panel marker sites were usable in your sample, which sets how confidently the ancestry cards are shown.
- [Vitamin B12 level](https://biome.you/glossary/trait/vitamin-b12-level) (Vitamins & nutrients, evidence: Low to moderate): Your genetically typical circulating vitamin B12 level.
- [Active B12 delivery](https://biome.you/glossary/trait/active-b12-delivery) (Vitamins & nutrients, evidence: Exploratory): How efficiently B12 is delivered into your cells, separate from total B12.
- [Folate processing (MTHFR)](https://biome.you/glossary/trait/folate-processing-mthfr) (Vitamins & nutrients, evidence: High): How efficiently your MTHFR enzyme processes folate, which influences homocysteine levels.
- [Vitamin D status tendency](https://biome.you/glossary/trait/vitamin-d-status-tendency) (Vitamins & nutrients, evidence: High): A GC variant that tilts your baseline vitamin D level via vitamin D-binding protein.
- [Omega-3 conversion (FADS1)](https://biome.you/glossary/trait/omega-3-conversion-fads1) (Vitamins & nutrients, evidence: Moderate): How efficiently your FADS1 enzyme converts plant omega-3 (ALA) into EPA and DHA.
- [Vitamin D level](https://biome.you/glossary/trait/vitamin-d-level) (Vitamins & nutrients, evidence: Moderate / emerging): Whether you carry a GC-gene variant linked to lower vitamin D levels.
- [Vitamin A from plants](https://biome.you/glossary/trait/vitamin-a-from-plants) (Vitamins & nutrients, evidence: Moderate when observed): How well you convert plant beta-carotene into active vitamin A.
- [Vitamin C absorption](https://biome.you/glossary/trait/vitamin-c-absorption) (Vitamins & nutrients, evidence: Low when observed): Whether you carry a variant that lowers vitamin C transport into cells.
- [Selenium level](https://biome.you/glossary/trait/selenium-level) (Minerals, evidence: Moderate): How your genes lean your circulating selenium level, a little higher or lower.
- [Blood-calcium set point (CASR)](https://biome.you/glossary/trait/blood-calcium-set-point-casr) (Minerals, evidence: Moderate): Whether your calcium-sensing receptor (CASR) variant nudges your blood-calcium set point upward.
- [Blood calcium via vitamin-D clearance (CYP24A1)](https://biome.you/glossary/trait/blood-calcium-via-vitamin-d-clearance-cyp24a1) (Minerals, evidence: Moderate): How your CYP24A1 variant, in the vitamin-D breakdown pathway, leans your blood calcium.
- [Blood copper level (SELENBP1)](https://biome.you/glossary/trait/blood-copper-level-selenbp1) (Minerals, evidence: Moderate): How your SELENBP1 variant leans your circulating blood-copper level.
- [Blood copper level (ceruloplasmin gene)](https://biome.you/glossary/trait/blood-copper-level-ceruloplasmin-gene) (Minerals, evidence: Moderate): How your variant near the ceruloplasmin (CP) gene leans your circulating blood-copper level.
- [Magnesium level (MUC1 marker)](https://biome.you/glossary/trait/magnesium-level-muc1-marker) (Minerals, evidence: Exploratory): How your genetics nudge where your blood magnesium tends to sit, from one of the two main magnesium markers.
- [Magnesium level (TRPM6 marker)](https://biome.you/glossary/trait/magnesium-level-trpm6-marker) (Minerals, evidence: Exploratory): A second magnesium marker where most people carry the lower-leaning version.
- [Zinc level (PPCDC marker)](https://biome.you/glossary/trait/zinc-level-ppcdc-marker) (Minerals, evidence: Moderate): How your genetics nudge your typical blood zinc, from the lead zinc marker.
- [Zinc level (CA1 marker)](https://biome.you/glossary/trait/zinc-level-ca1-marker) (Minerals, evidence: Moderate): A second zinc marker adding to your blood-zinc tendency.
- [Iron level (TMPRSS6 marker)](https://biome.you/glossary/trait/iron-level-tmprss6-marker) (Minerals, evidence: High): How your genetics nudge your iron markers, from the main iron-regulation gene.
- [Iron level (TF marker)](https://biome.you/glossary/trait/iron-level-tf-marker) (Minerals, evidence: Moderate): A second iron marker reflecting iron transport rather than storage.
- [How you metabolize CYP2C19 drugs](https://biome.you/glossary/trait/how-you-metabolize-cyp2c19-drugs) (Medication response, evidence: High when call is present): How your body processes drugs handled by the CYP2C19 enzyme, such as some antidepressants, acid-reflux PPIs, and the antiplatelet drug clopidogrel.
- [How you metabolize CYP2D6 drugs](https://biome.you/glossary/trait/how-you-metabolize-cyp2d6-drugs) (Medication response, evidence: High when call is present): How your body processes drugs handled by the CYP2D6 enzyme, including many antidepressants, opioid painkillers like codeine and tramadol, and some beta blockers.
- [How you metabolize CYP2C9 drugs](https://biome.you/glossary/trait/how-you-metabolize-cyp2c9-drugs) (Medication response, evidence: High when call is present): How your body processes drugs handled by the CYP2C9 enzyme, including NSAIDs, warfarin, and the seizure medicine phenytoin.
- [Warfarin dose sensitivity (VKORC1)](https://biome.you/glossary/trait/warfarin-dose-sensitivity-vkorc1) (Medication response, evidence: High when call is present): How sensitive you are to the blood thinner warfarin, based on the VKORC1 gene — higher sensitivity usually means a lower dose.
- [Statin muscle-symptom risk (SLCO1B1)](https://biome.you/glossary/trait/statin-muscle-symptom-risk-slco1b1) (Medication response, evidence: High when call is present): How well the SLCO1B1 transporter moves statins out of your bloodstream — lower function raises the chance of statin-related muscle aches.
- [Statin & urate-drug transport (ABCG2)](https://biome.you/glossary/trait/statin-urate-drug-transport-abcg2) (Medication response, evidence: High when call is present): How well the ABCG2 transporter moves rosuvastatin and certain urate-lowering drugs — reduced function raises drug levels and is linked to gout risk.
- [GLP-1 weight-loss drug response markers](https://biome.you/glossary/trait/glp-1-weight-loss-drug-response-markers) (Medication response, evidence: Moderate / emerging): Two research markers linked to how you might respond to GLP-1 weight-loss drugs — one to weight-loss amount (GLP1R), one to nausea on tirzepatide-type drugs (GIPR).
- [How you metabolize CYP2B6 drugs](https://biome.you/glossary/trait/how-you-metabolize-cyp2b6-drugs) (Medication response, evidence: High when call is present): How your body processes drugs handled by the CYP2B6 enzyme, most notably the HIV medicine efavirenz.
- [How you metabolize CYP3A5 drugs (e.g. tacrolimus)](https://biome.you/glossary/trait/how-you-metabolize-cyp3a5-drugs-e-g-tacrolimus) (Medication response, evidence: High when call is present): Whether you make an active CYP3A5 enzyme, which mainly guides dosing of the transplant drug tacrolimus — expressers often need higher doses.
- [Chemotherapy (fluoropyrimidine) tolerance (DPYD)](https://biome.you/glossary/trait/chemotherapy-fluoropyrimidine-tolerance-dpyd) (Medication response, evidence: High when call is present): How well the DPD enzyme breaks down fluoropyrimidine chemotherapy drugs (5-FU, capecitabine) — lower activity raises the risk of severe side effects.
- [Thiopurine drug clearance](https://biome.you/glossary/trait/thiopurine-drug-clearance) (Medication response, evidence: High when call is present): How quickly your body clears thiopurine drugs such as azathioprine and mercaptopurine, which sets a safe dose.
- [Thiopurine sensitivity](https://biome.you/glossary/trait/thiopurine-sensitivity) (Medication response, evidence: High when call is present): How sensitive you are to thiopurine drugs; reduced-function types risk toxicity and need lower doses.
- [Bilirubin & drug clearance (UGT1A1)](https://biome.you/glossary/trait/bilirubin-drug-clearance-ugt1a1) (Medication response, evidence: High when call is present): How well you process bilirubin and drugs like irinotecan; reduced function underlies Gilbert's syndrome and higher drug toxicity.
- [Anesthesia reaction risk (CACNA1S)](https://biome.you/glossary/trait/anesthesia-reaction-risk-cacna1s) (Medication response, evidence: High when call is present): Whether you carry a rare CACNA1S variant linked to a dangerous reaction to certain anesthesia drugs.
- [Anesthesia recovery (muscle relaxants)](https://biome.you/glossary/trait/anesthesia-recovery-muscle-relaxants) (Medication response, evidence: High when call is present): How fast you clear the anesthesia muscle-relaxant succinylcholine; reduced function can prolong its effect.
- [Sleep timing (morning vs evening)](https://biome.you/glossary/trait/sleep-timing-morning-vs-evening) (Sleep & chronotype, evidence: Moderate when calibrated): Whether your genes lean you toward being a morning lark or a night owl.
- [Insomnia tendency](https://biome.you/glossary/trait/insomnia-tendency) (Sleep & chronotype, evidence: Exploratory): A modest genetic lean toward difficulty falling or staying asleep.
- [Natural sleep length](https://biome.you/glossary/trait/natural-sleep-length) (Sleep & chronotype, evidence: Exploratory when present): A small genetic lean toward a naturally shorter or longer night's sleep.
- [REM vs deep-sleep balance (MEIS1)](https://biome.you/glossary/trait/rem-vs-deep-sleep-balance-meis1) (Sleep & chronotype, evidence: High): How your MEIS1 variant tilts the balance between REM and deep (NREM) sleep.
- [Endurance tendency](https://biome.you/glossary/trait/endurance-tendency) (Fitness & performance, evidence: Exploratory): An exploratory genetic lean in natural aerobic endurance.
- [Aerobic capacity](https://biome.you/glossary/trait/aerobic-capacity) (Fitness & performance, evidence: Exploratory): An exploratory genetic lean in your body's aerobic capacity (VO₂ max).
- [Genetic activity drive](https://biome.you/glossary/trait/genetic-activity-drive) (Fitness & performance, evidence: Exploratory): A very small genetic lean in how inclined you are toward physical activity.
- [Tendon & ligament injury tendency](https://biome.you/glossary/trait/tendon-ligament-injury-tendency) (Fitness & performance, evidence: Low): How your collagen (COL5A1) gene leans your tendons and ligaments toward soft-tissue injury.
- [Power vs endurance muscle](https://biome.you/glossary/trait/power-vs-endurance-muscle) (Fitness & performance, evidence: Moderate): Whether your ACTN3 gene favors powerful, explosive muscle or endurance.
- [Endurance training response](https://biome.you/glossary/trait/endurance-training-response) (Fitness & performance, evidence: Low): How much your aerobic fitness may improve in response to endurance training.
- [Sex-hormone transport (SHBG)](https://biome.you/glossary/trait/sex-hormone-transport-shbg) (Hormone pathways, evidence: Moderate with ancestry caveat): Two common variants that shift how much sex hormone-binding globulin you carry — about 11% per copy of the lead variant, roughly 23% between the two ends, and slightly stronger in men than women. SHBG ferries testosterone and estradiol through the blood, so it changes what a total testosterone reading means, not how much active hormone you have. Measured only in European-ancestry groups, and the lead variant is close to absent in East Asian groups; ask for SHBG and free testosterone alongside a total testosterone test.
- [Estrogen production (aromatase)](https://biome.you/glossary/trait/estrogen-production-aromatase) (Hormone pathways, evidence: Low): How active your aromatase enzyme is, which converts testosterone into estrogen.
- [Testosterone tendency](https://biome.you/glossary/trait/testosterone-tendency) (Hormone pathways, evidence: Moderate): A variant linked to slightly higher or lower baseline testosterone, studied mainly in European men.
- [IGF-1 level tendency](https://biome.you/glossary/trait/igf-1-level-tendency) (Hormone pathways, evidence: High): A modest genetic lean toward higher or lower circulating IGF-1, a growth factor.
- [FOXO3 longevity variant](https://biome.you/glossary/trait/foxo3-longevity-variant) (Stress, longevity & antioxidants, evidence: Moderate): How many copies you carry of a FOXO3 variant enriched in people who live to very old age.
- [Antioxidant enzyme (SOD2)](https://biome.you/glossary/trait/antioxidant-enzyme-sod2) (Stress, longevity & antioxidants, evidence: Low): How efficiently your SOD2 antioxidant enzyme reaches the mitochondria where it neutralizes oxidative stress.
- [Stress-response gene (FKBP5)](https://biome.you/glossary/trait/stress-response-gene-fkbp5) (Stress, longevity & antioxidants, evidence: Exploratory): How strongly your cortisol stress-response system reacts, influenced by the FKBP5 gene.
- [Skin oiliness](https://biome.you/glossary/trait/skin-oiliness) (Skin & connective tissue, evidence: Low to moderate): A directional genetic lean in how oily or dry your skin tends to run.
- [Collagen strength](https://biome.you/glossary/trait/collagen-strength) (Skin & connective tissue, evidence: High): Whether a COL1A1 variant leaves your type I collagen at baseline strength or slightly reduced.
- [Soft-tissue injury tendency](https://biome.you/glossary/trait/soft-tissue-injury-tendency) (Skin & connective tissue, evidence: Moderate): How a COL5A1 variant leans your odds of tendon and ligament soft-tissue injury.
- [TNF-α inflammatory signalling](https://biome.you/glossary/trait/tnf-inflammatory-signalling) (Skin & connective tissue, evidence: Low): Whether you carry the promoter variant linked to slightly higher TNF-α, an inflammatory signalling molecule.
- [Skin matrix remodeling](https://biome.you/glossary/trait/skin-matrix-remodeling) (Skin & connective tissue, evidence: Exploratory when observed): How actively your skin's MMP1 enzyme breaks down and rebuilds collagen.
- [GSTM1 detox enzyme](https://biome.you/glossary/trait/gstm1-detox-enzyme) (Cognition & methylation, evidence: Moderate): Whether both copies of the GSTM1 detox gene are deleted (null) or you keep enzyme activity.
- [GSTT1 detox enzyme](https://biome.you/glossary/trait/gstt1-detox-enzyme) (Cognition & methylation, evidence: Moderate): Whether both copies of the GSTT1 detox gene are deleted (null) or you keep enzyme activity.
- [Dopamine clearance speed](https://biome.you/glossary/trait/dopamine-clearance-speed) (Cognition & methylation, evidence: Exploratory): How quickly your COMT enzyme clears dopamine and related stress chemicals.
- [Neuroplasticity signaling (BDNF)](https://biome.you/glossary/trait/neuroplasticity-signaling-bdnf) (Cognition & methylation, evidence: Exploratory when observed): A BDNF variant that subtly tunes the activity-driven signaling behind learning and plasticity.
- [Appetite & weight tendency](https://biome.you/glossary/trait/appetite-weight-tendency) (Weight & metabolism, evidence: Exploratory): How your MC4R appetite gene leans your food intake and body-weight set point.
- [Appetite & fullness tendency](https://biome.you/glossary/trait/appetite-fullness-tendency) (Weight & metabolism, evidence: Exploratory): Whether your genetics lean toward feeling hungrier sooner, from the main appetite gene.
- [Gut secretor status](https://biome.you/glossary/trait/gut-secretor-status) (Gut health, evidence: Moderate): Whether your FUT2 gene releases blood-group sugars into your gut and saliva, which helps shape your microbiome.
- [Thyroid hormone activation (bloodstream)](https://biome.you/glossary/trait/thyroid-hormone-activation-bloodstream) (Thyroid, evidence: Moderate): Which direction your D1 enzyme shifts the balance between thyroid T4 and active T3 in your bloodstream.
- [Thyroid hormone activation (tissue)](https://biome.you/glossary/trait/thyroid-hormone-activation-tissue) (Thyroid, evidence: Moderate): How well your D2 enzyme produces active thyroid T3 locally inside tissues.
- [Nicotine dependence tendency](https://biome.you/glossary/trait/nicotine-dependence-tendency) (Behavioral, evidence: Moderate): A well-replicated CHRNA5 variant tied to heavier smoking and nicotine dependence in people who smoke.
- [Uric-acid clearance & gout risk (ABCG2)](https://biome.you/glossary/trait/uric-acid-clearance-gout-risk-abcg2) (Health risks, evidence: Moderate): How your ABCG2 (Q141K) variant affects uric-acid clearance and your leaning toward gout.
- [Uric-acid reabsorption & gout risk (GLUT9)](https://biome.you/glossary/trait/uric-acid-reabsorption-gout-risk-glut9) (Health risks, evidence: Moderate): How your GLUT9 transporter variant leans your uric-acid reabsorption and gout risk.
- [Coronary artery disease risk](https://biome.you/glossary/trait/coronary-artery-disease-risk) (Health risks, evidence: High): Your genetic tendency toward coronary artery disease, scored against people of European ancestry.
- [Type 2 diabetes risk](https://biome.you/glossary/trait/type-2-diabetes-risk) (Health risks, evidence: High): Your genetic tendency toward type 2 diabetes, combining a genome-wide score with the single strongest diabetes gene variant (TCF7L2).
- [Atrial fibrillation risk](https://biome.you/glossary/trait/atrial-fibrillation-risk) (Health risks, evidence: High): Your genetic tendency toward atrial fibrillation, an irregular and often rapid heart rhythm.
- [Osteoporosis risk (bone density)](https://biome.you/glossary/trait/osteoporosis-risk-bone-density) (Health risks, evidence: High): Your genetically estimated bone density, which shapes how prone you are to low bone density and fractures.
- [Inflammatory bowel disease risk](https://biome.you/glossary/trait/inflammatory-bowel-disease-risk) (Health risks, evidence: High): Your genetic tendency toward inflammatory bowel disease (Crohn's disease and ulcerative colitis).
- [Glaucoma risk](https://biome.you/glossary/trait/glaucoma-risk) (Health risks, evidence: High): Your genetic tendency toward primary open-angle glaucoma, a leading cause of irreversible vision loss.
- [Asthma and allergy risk](https://biome.you/glossary/trait/asthma-and-allergy-risk) (Health risks, evidence: High): Your genetic tendency toward asthma and related allergic conditions.
- [Restless legs syndrome risk](https://biome.you/glossary/trait/restless-legs-syndrome-risk) (Health risks, evidence: Moderate to high): A broad genetic lean toward restless legs syndrome; the evidence isn't precise enough for a percentile.
- [Late-eating blood-sugar response](https://biome.you/glossary/trait/late-eating-blood-sugar-response) (Health risks, evidence: Moderate to high): An MTNR1B variant that shapes how much late-night eating nudges your blood sugar via melatonin signaling.
- [Anesthesia reaction risk (RYR1)](https://biome.you/glossary/trait/anesthesia-reaction-risk-ryr1) (Health risks, evidence: High when call is present): Whether you carry an RYR1 variant linked to a dangerous reaction to certain anesthesia drugs.
- [Ivacaftor response (CFTR)](https://biome.you/glossary/trait/ivacaftor-response-cftr) (Health risks, evidence: High when call is present): Whether you carry a CFTR variant that responds to the cystic-fibrosis drug ivacaftor.
- [Inherited blood-clot risk](https://biome.you/glossary/trait/inherited-blood-clot-risk) (Health risks, evidence: High when call is present): Whether you carry Factor V Leiden or Prothrombin 20210A, two inherited variants that raise the odds of abnormal blood clots.
- [Inherited iron-overload risk](https://biome.you/glossary/trait/inherited-iron-overload-risk) (Health risks, evidence: High when call is present): Whether your HFE gene carries the C282Y/H63D combinations linked to hereditary hemochromatosis (iron overload).
- [APOE Alzheimer's-risk type](https://biome.you/glossary/trait/apoe-alzheimers-risk-type) (Health risks, evidence: High when call is present): Your APOE gene type (ε2/ε3/ε4), the strongest common genetic factor in late-onset Alzheimer's risk.
- [Inherited Parkinson's-risk variants](https://biome.you/glossary/trait/inherited-parkinsons-risk-variants) (Health risks, evidence: High when call is present): Whether you carry LRRK2 G2019S or GBA1 N370S, two well-established genetic risk factors for Parkinson's disease.
- [Celiac genetic risk type](https://biome.you/glossary/trait/celiac-genetic-risk-type) (Health risks, evidence: High when call is present): Whether you carry the HLA-DQ2/DQ8 immune types found in nearly all celiac disease — most useful for ruling celiac out when absent.
- [Fatty-liver genetic tendency](https://biome.you/glossary/trait/fatty-liver-genetic-tendency) (Health risks, evidence: High): A small two-gene nudge (PNPLA3, TM6SF2) toward fatty liver — context, not a diagnosis.
- [Macular degeneration (AMD) risk](https://biome.you/glossary/trait/macular-degeneration-amd-risk) (Health risks, evidence: High): Your combined CFH and ARMS2 risk-allele count, the two strongest common genetic factors in age-related macular degeneration.
- [PCOS genetic tendency](https://biome.you/glossary/trait/pcos-genetic-tendency) (Health risks, evidence: Moderate): A small three-gene tendency toward polycystic ovary syndrome (PCOS) — context, not a diagnosis.

### Genes

- [ABCC11](https://biome.you/glossary/gene/abcc11)
- [ABCG2](https://biome.you/glossary/gene/abcg2)
- [ACTN3](https://biome.you/glossary/gene/actn3)
- [ADARB2](https://biome.you/glossary/gene/adarb2)
- [ADCY2](https://biome.you/glossary/gene/adcy2)
- [ADH1B](https://biome.you/glossary/gene/adh1b)
- [ADORA2A](https://biome.you/glossary/gene/adora2a)
- [AHR](https://biome.you/glossary/gene/ahr)
- [ALDH2](https://biome.you/glossary/gene/aldh2)
- [AMPD1](https://biome.you/glossary/gene/ampd1)
- [APOE](https://biome.you/glossary/gene/apoe)
- [ARMS2](https://biome.you/glossary/gene/arms2)
- [ARNTL](https://biome.you/glossary/gene/arntl)
- [ATG16L1](https://biome.you/glossary/gene/atg16l1)
- [BCHE](https://biome.you/glossary/gene/bche)
- [BCO1](https://biome.you/glossary/gene/bco1)
- [BDNF](https://biome.you/glossary/gene/bdnf)
- [BMAL1](https://biome.you/glossary/gene/bmal1)
- [BTBD9](https://biome.you/glossary/gene/btbd9)
- [CA1](https://biome.you/glossary/gene/ca1)
- [CACNA1S](https://biome.you/glossary/gene/cacna1s)
- [CALCB](https://biome.you/glossary/gene/calcb)
- [CASR](https://biome.you/glossary/gene/casr)
- [CBS](https://biome.you/glossary/gene/cbs)
- [CDKN2B](https://biome.you/glossary/gene/cdkn2b)
- [CFH](https://biome.you/glossary/gene/cfh)
- [CFTR](https://biome.you/glossary/gene/cftr)
- [CHRNA5](https://biome.you/glossary/gene/chrna5)
- [COL1A1](https://biome.you/glossary/gene/col1a1)
- [COL5A1](https://biome.you/glossary/gene/col5a1)
- [COMT](https://biome.you/glossary/gene/comt)
- [COPB1](https://biome.you/glossary/gene/copb1)
- [CP](https://biome.you/glossary/gene/cp)
- [CYP19A1](https://biome.you/glossary/gene/cyp19a1)
- [CYP1A1](https://biome.you/glossary/gene/cyp1a1)
- [CYP1A2](https://biome.you/glossary/gene/cyp1a2)
- [CYP24A1](https://biome.you/glossary/gene/cyp24a1)
- [CYP2B6](https://biome.you/glossary/gene/cyp2b6)
- [CYP2C19](https://biome.you/glossary/gene/cyp2c19)
- [CYP2C9](https://biome.you/glossary/gene/cyp2c9)
- [CYP2D6](https://biome.you/glossary/gene/cyp2d6)
- [CYP3A5](https://biome.you/glossary/gene/cyp3a5)
- [DENND1A](https://biome.you/glossary/gene/dennd1a)
- [DIO1](https://biome.you/glossary/gene/dio1)
- [DIO2](https://biome.you/glossary/gene/dio2)
- [DPYD](https://biome.you/glossary/gene/dpyd)
- [EDA2R](https://biome.you/glossary/gene/eda2r)
- [F2](https://biome.you/glossary/gene/f2)
- [F5](https://biome.you/glossary/gene/f5)
- [FADS1](https://biome.you/glossary/gene/fads1)
- [FKBP5](https://biome.you/glossary/gene/fkbp5)
- [FOXO3](https://biome.you/glossary/gene/foxo3)
- [FSHB](https://biome.you/glossary/gene/fshb)
- [FTO](https://biome.you/glossary/gene/fto)
- [FUT2](https://biome.you/glossary/gene/fut2)
- [GBA](https://biome.you/glossary/gene/gba)
- [GC](https://biome.you/glossary/gene/gc)
- [GIPR](https://biome.you/glossary/gene/gipr)
- [GLP1R](https://biome.you/glossary/gene/glp1r)
- [GLUT9](https://biome.you/glossary/gene/glut9)
- [GSDMB](https://biome.you/glossary/gene/gsdmb)
- [GSTM1](https://biome.you/glossary/gene/gstm1)
- [GSTT1](https://biome.you/glossary/gene/gstt1)
- [HERC2](https://biome.you/glossary/gene/herc2)
- [HFE](https://biome.you/glossary/gene/hfe)
- [HTRA1](https://biome.you/glossary/gene/htra1)
- [IGF1](https://biome.you/glossary/gene/igf1)
- [IL1RL1](https://biome.you/glossary/gene/il1rl1)
- [IL23R](https://biome.you/glossary/gene/il23r)
- [IL33](https://biome.you/glossary/gene/il33)
- [IRF4](https://biome.you/glossary/gene/irf4)
- [JMJD1C](https://biome.you/glossary/gene/jmjd1c)
- [KCNN3](https://biome.you/glossary/gene/kcnn3)
- [LCT](https://biome.you/glossary/gene/lct)
- [LHCGR](https://biome.you/glossary/gene/lhcgr)
- [LPA](https://biome.you/glossary/gene/lpa)
- [LRRK2](https://biome.you/glossary/gene/lrrk2)
- [LTA](https://biome.you/glossary/gene/lta)
- [MC4R](https://biome.you/glossary/gene/mc4r)
- [MCM6](https://biome.you/glossary/gene/mcm6)
- [MEIS1](https://biome.you/glossary/gene/meis1)
- [MMP1](https://biome.you/glossary/gene/mmp1)
- [MTHFR](https://biome.you/glossary/gene/mthfr)
- [MTNR1B](https://biome.you/glossary/gene/mtnr1b)
- [MUC1](https://biome.you/glossary/gene/muc1)
- [NOD2](https://biome.you/glossary/gene/nod2)
- [NUDT15](https://biome.you/glossary/gene/nudt15)
- [OCA2](https://biome.you/glossary/gene/oca2)
- [OR4A16](https://biome.you/glossary/gene/or4a16)
- [OR5A2](https://biome.you/glossary/gene/or5a2)
- [OR6A2](https://biome.you/glossary/gene/or6a2)
- [ORMDL3](https://biome.you/glossary/gene/ormdl3)
- [PCSK9](https://biome.you/glossary/gene/pcsk9)
- [PDE3B](https://biome.you/glossary/gene/pde3b)
- [PGS002311](https://biome.you/glossary/gene/pgs002311)
- [PITX2](https://biome.you/glossary/gene/pitx2)
- [PNPLA3](https://biome.you/glossary/gene/pnpla3)
- [PPARGC1A](https://biome.you/glossary/gene/ppargc1a)
- [PPCDC](https://biome.you/glossary/gene/ppcdc)
- [PSMA1](https://biome.you/glossary/gene/psma1)
- [PTPRD](https://biome.you/glossary/gene/ptprd)
- [RXRA](https://biome.you/glossary/gene/rxra)
- [RYR1](https://biome.you/glossary/gene/ryr1)
- [SELENBP1](https://biome.you/glossary/gene/selenbp1)
- [SHBG](https://biome.you/glossary/gene/shbg)
- [SIX1](https://biome.you/glossary/gene/six1)
- [SLC23A1](https://biome.you/glossary/gene/slc23a1)
- [SLC2A9](https://biome.you/glossary/gene/slc2a9)
- [SLCO1B1](https://biome.you/glossary/gene/slco1b1)
- [SOD2](https://biome.you/glossary/gene/sod2)
- [SOX9](https://biome.you/glossary/gene/sox9)
- [TAS1R3](https://biome.you/glossary/gene/tas1r3)
- [TAS2R38](https://biome.you/glossary/gene/tas2r38)
- [TCF7L2](https://biome.you/glossary/gene/tcf7l2)
- [TCN2](https://biome.you/glossary/gene/tcn2)
- [TF](https://biome.you/glossary/gene/tf)
- [TM6SF2](https://biome.you/glossary/gene/tm6sf2)
- [TMCO1](https://biome.you/glossary/gene/tmco1)
- [TMPRSS6](https://biome.you/glossary/gene/tmprss6)
- [TNF](https://biome.you/glossary/gene/tnf)
- [TPMT](https://biome.you/glossary/gene/tpmt)
- [TRIM46](https://biome.you/glossary/gene/trim46)
- [TRPM6](https://biome.you/glossary/gene/trpm6)
- [UGT1A1](https://biome.you/glossary/gene/ugt1a1)
- [VKORC1](https://biome.you/glossary/gene/vkorc1)
- [ZEB2](https://biome.you/glossary/gene/zeb2)
- [ZFHX3](https://biome.you/glossary/gene/zfhx3)

### Markers (rsIDs)

- [rs671](https://biome.you/glossary/marker/rs671)
- [rs4680](https://biome.you/glossary/marker/rs4680)
- [rs4880](https://biome.you/glossary/marker/rs4880)
- [rs6025](https://biome.you/glossary/marker/rs6025)
- [rs6265](https://biome.you/glossary/marker/rs6265)
- [rs7412](https://biome.you/glossary/marker/rs7412)
- [rs10046](https://biome.you/glossary/marker/rs10046)
- [rs12722](https://biome.you/glossary/marker/rs12722)
- [rs35767](https://biome.you/glossary/marker/rs35767)
- [rs174537](https://biome.you/glossary/marker/rs174537)
- [rs225014](https://biome.you/glossary/marker/rs225014)
- [rs307355](https://biome.you/glossary/marker/rs307355)
- [rs429358](https://biome.you/glossary/marker/rs429358)
- [rs601338](https://biome.you/glossary/marker/rs601338)
- [rs602662](https://biome.you/glossary/marker/rs602662)
- [rs669453](https://biome.you/glossary/marker/rs669453)
- [rs713598](https://biome.you/glossary/marker/rs713598)
- [rs738409](https://biome.you/glossary/marker/rs738409)
- [rs855791](https://biome.you/glossary/marker/rs855791)
- [rs992969](https://biome.you/glossary/marker/rs992969)
- [rs1061170](https://biome.you/glossary/marker/rs1061170)
- [rs1229984](https://biome.you/glossary/marker/rs1229984)
- [rs1333049](https://biome.you/glossary/marker/rs1333049)
- [rs1360780](https://biome.you/glossary/marker/rs1360780)
- [rs1385699](https://biome.you/glossary/marker/rs1385699)
- [rs1532423](https://biome.you/glossary/marker/rs1532423)
- [rs1570669](https://biome.you/glossary/marker/rs1570669)
- [rs1726866](https://biome.you/glossary/marker/rs1726866)
- [rs1789953](https://biome.you/glossary/marker/rs1789953)
- [rs1799750](https://biome.you/glossary/marker/rs1799750)
- [rs1799807](https://biome.you/glossary/marker/rs1799807)
- [rs1799945](https://biome.you/glossary/marker/rs1799945)
- [rs1799963](https://biome.you/glossary/marker/rs1799963)
- [rs1800012](https://biome.you/glossary/marker/rs1800012)
- [rs1800437](https://biome.you/glossary/marker/rs1800437)
- [rs1800562](https://biome.you/glossary/marker/rs1800562)
- [rs1800629](https://biome.you/glossary/marker/rs1800629)
- [rs1801133](https://biome.you/glossary/marker/rs1801133)
- [rs1801198](https://biome.you/glossary/marker/rs1801198)
- [rs1801725](https://biome.you/glossary/marker/rs1801725)
- [rs1803274](https://biome.you/glossary/marker/rs1803274)
- [rs1815739](https://biome.you/glossary/marker/rs1815739)
- [rs2066844](https://biome.you/glossary/marker/rs2066844)
- [rs2066845](https://biome.you/glossary/marker/rs2066845)
- [rs2066847](https://biome.you/glossary/marker/rs2066847)
- [rs2120019](https://biome.you/glossary/marker/rs2120019)
- [rs2187668](https://biome.you/glossary/marker/rs2187668)
- [rs2200733](https://biome.you/glossary/marker/rs2200733)
- [rs2231142](https://biome.you/glossary/marker/rs2231142)
- [rs2235544](https://biome.you/glossary/marker/rs2235544)
- [rs2241880](https://biome.you/glossary/marker/rs2241880)
- [rs2282679](https://biome.you/glossary/marker/rs2282679)
- [rs2472297](https://biome.you/glossary/marker/rs2472297)
- [rs2769264](https://biome.you/glossary/marker/rs2769264)
- [rs2802292](https://biome.you/glossary/marker/rs2802292)
- [rs3798220](https://biome.you/glossary/marker/rs3798220)
- [rs3811647](https://biome.you/glossary/marker/rs3811647)
- [rs4072037](https://biome.you/glossary/marker/rs4072037)
- [rs4410790](https://biome.you/glossary/marker/rs4410790)
- [rs4481887](https://biome.you/glossary/marker/rs4481887)
- [rs4656461](https://biome.you/glossary/marker/rs4656461)
- [rs4795399](https://biome.you/glossary/marker/rs4795399)
- [rs4977756](https://biome.you/glossary/marker/rs4977756)
- [rs4988235](https://biome.you/glossary/marker/rs4988235)
- [rs5751876](https://biome.you/glossary/marker/rs5751876)
- [rs7193343](https://biome.you/glossary/marker/rs7193343)
- [rs7442295](https://biome.you/glossary/marker/rs7442295)
- [rs7454108](https://biome.you/glossary/marker/rs7454108)
- [rs7501331](https://biome.you/glossary/marker/rs7501331)
- [rs7903146](https://biome.you/glossary/marker/rs7903146)
- [rs7904615](https://biome.you/glossary/marker/rs7904615)
- [rs7910927](https://biome.you/glossary/marker/rs7910927)
- [rs8192678](https://biome.you/glossary/marker/rs8192678)
- [rs9939609](https://biome.you/glossary/marker/rs9939609)
- [rs10246939](https://biome.you/glossary/marker/rs10246939)
- [rs10305420](https://biome.you/glossary/marker/rs10305420)
- [rs10427255](https://biome.you/glossary/marker/rs10427255)
- [rs10455872](https://biome.you/glossary/marker/rs10455872)
- [rs10483727](https://biome.you/glossary/marker/rs10483727)
- [rs10490924](https://biome.you/glossary/marker/rs10490924)
- [rs10818854](https://biome.you/glossary/marker/rs10818854)
- [rs10822184](https://biome.you/glossary/marker/rs10822184)
- [rs10830963](https://biome.you/glossary/marker/rs10830963)
- [rs11031006](https://biome.you/glossary/marker/rs11031006)
- [rs11144134](https://biome.you/glossary/marker/rs11144134)
- [rs11209026](https://biome.you/glossary/marker/rs11209026)
- [rs11591147](https://biome.you/glossary/marker/rs11591147)
- [rs12150660](https://biome.you/glossary/marker/rs12150660)
- [rs12203592](https://biome.you/glossary/marker/rs12203592)
- [rs12913832](https://biome.you/glossary/marker/rs12913832)
- [rs13376333](https://biome.you/glossary/marker/rs13376333)
- [rs13405728](https://biome.you/glossary/marker/rs13405728)
- [rs16969968](https://biome.you/glossary/marker/rs16969968)
- [rs17602729](https://biome.you/glossary/marker/rs17602729)
- [rs17782313](https://biome.you/glossary/marker/rs17782313)
- [rs17822931](https://biome.you/glossary/marker/rs17822931)
- [rs33972313](https://biome.you/glossary/marker/rs33972313)
- [rs34637584](https://biome.you/glossary/marker/rs34637584)
- [rs35691438](https://biome.you/glossary/marker/rs35691438)
- [rs58542926](https://biome.you/glossary/marker/rs58542926)
- [rs61902559](https://biome.you/glossary/marker/rs61902559)
- [rs72823641](https://biome.you/glossary/marker/rs72823641)
- [rs72921001](https://biome.you/glossary/marker/rs72921001)
- [rs76763715](https://biome.you/glossary/marker/rs76763715)
- [rs113851554](https://biome.you/glossary/marker/rs113851554)
- [rs115366859](https://biome.you/glossary/marker/rs115366859)
- [rs116058752](https://biome.you/glossary/marker/rs116058752)